Methylprednisolone and its related substances in freeze dried powders for injections

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Methylprednisolone and its related substances in freeze-dried powders for injections

In this work behavior of active pharmaceutical substances  methylprednisolone (in a form of methylprednisolone sodium succinate) in finished pharmaceutical dosage form – freeze dried powder for injections was examined. The goal was to evaluate the chemical stabilities of methylprednisolone sodium succinate packaged in dual chamber vial, as a specific container closure system. The effect of dif...

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Physicochemical and antioxidant studies on oven-dried, freeze-dried and spray-dried agaro-oligosaccharide powders

In this work, oven-dried, freeze-dried and spray-dried agaro-oligosaccharide powders were characterized to investigate their physicochemical and antioxidant properties. Agarooligosaccharide powders were shown to exhibit high water solubility index (88.73 – 95.88%), water absorption capacity (0.96 – 2.57 g/g) and oil absorption capacity (0.40 – 0.45 g/g). Agarooligosaccharide powders were shown ...

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Freeze-dried B.C.G.

Freeze-dried B.C.G. of British manufacture became available for experimental work in 1955. The main reason for introducing it was the need for a vaccine which would retain its potency under conditions of prolonged storage. On reconstitution for injection the vaccine should produce a uniform suspension with minimal clumping, resulting in a uniform viable bacterial count. These properties mean th...

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Inaccuracies in measurement of dried milk powders.

Infant feeds made up from dried milk are known to be hazardous if the mixture is too concentrated. Tests with five commercial brands of dried milk showed that nurses, midwives, and mothers often made up feeds incorrectly; in most cases the amount of powder used was excessive.Fewer mistakes would be made if scoops were standardized or, better, if the milk was made up in small, accurately weighed...

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A stability-Indicating HPLC Method for Simultaneous Determination of Creatine Phosphate Sodium and its Related Substances in Pharmaceutical Formulation

The objective of the study was to develop a simple, specific and stability-indicating HPLC method for the simultaneous determination of creatine phosphate sodium (CPS) and its related substances in pharmaceutical formulation. Separation of creatine phosphate sodium from its major process impurities and degradation products was achieved on a Hypersil BDS C18 column (250 × 4.6 mm, 5 μm) with an a...

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ژورنال

عنوان ژورنال: Journal of the Serbian Chemical Society

سال: 2010

ISSN: 0352-5139,1820-7421

DOI: 10.2298/jsc100115087s